Zepbound® (tirzepatide) is a prescription medication used for chronic weight management in adults diagnosed with obesity, or in adults with overweight and at least one weight-related medical condition such as high blood pressure, high cholesterol, or type 2 diabetes.

Zepbound is meant to be used alongside a reduced-calorie diet and increased physical activity. It is not a stimulant, appetite suppressant, or short-term weight-loss medication. Zepbound provides a structured, long-term approach to weight management supported by clinical research.

Zepbound contains tirzepatide, a medication that activates two incretin hormone receptors: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). This dual action is unique to tirzepatide.

By stimulating both pathways, Zepbound helps:

• Reduce appetite by acting on areas of the brain involved in hunger regulation.

• Slow gastric emptying, helping you feel fuller for longer.

• Improve glucose control through regulated insulin release.

• Support overall metabolic function in conjunction with lifestyle changes.

This combined mechanism contributes to meaningful weight reduction for many adults.

In clinical trials, adults using Zepbound in combination with lifestyle changes experienced significant weight reduction, with many achieving double-digit percentage loss of their total body weight. Individual results vary and depend on factors including dose, consistency, diet, physical activity, and personal metabolic response.

Zepbound is intended for long-term use, and benefits build over time. A healthcare provider will determine the appropriate dosage schedule.

Many individuals begin to notice changes in appetite or fullness within the first few weeks. Weight reduction typically occurs gradually as the dose increases and your body adjusts.

For metabolic and appetite effects, it may take several weeks to months to see full benefit. Because Zepbound is taken weekly, consistent use is essential for optimal outcomes.

Zepbound is approved for adults who meet one of the following criteria:

• BMI of 30 or higher (obesity)

• BMI of 27 or higher with at least one weight-related condition

Weight-related conditions may include high blood pressure, high cholesterol, type 2 diabetes, or sleep apnea. A Good Girl Rx provider will review your medical history to ensure Zepbound is safe and appropriate for you.

Zepbound is not recommended for individuals with a personal/family history of MTC, MEN 2, pancreatitis, or severe gastrointestinal disease.

The most commonly reported side effects tend to affect the digestive system. These may include:

• Nausea

• Vomiting

• Diarrhea

• Constipation

• Stomach upset or discomfort

These side effects are usually temporary and may decrease as your body adjusts. Staying hydrated and eating smaller meals may help. Always contact your provider if symptoms persist or worsen.

Unlike traditional GLP-1 medications that act on a single hormone pathway, Zepbound activates both GLP-1 and GIP receptors. This dual-receptor mechanism is designed to enhance metabolic effects related to appetite, digestion, insulin response, and overall energy balance.

Because of this dual action, some individuals may experience more pronounced benefits than with single-hormone GLP-1 agonists. However, results vary by person.

No. Zepbound should not be taken with other GLP-1 receptor agonists, GIP agonists, or tirzepatide-containing medications. Combining medications that act on the same pathways may increase the risk of adverse effects.

A Good Girl Rx provider will assess your current medications to ensure there are no conflicts.

Insurance coverage varies widely. Some commercial insurance plans may cover Zepbound for qualifying patients, while others may not include weight management medications.

At Good Girl Rx, you can choose one of two pathways:

• Insurance: We verify your benefits, determine eligibility, and handle all claim processing.

• Cash-pay: If insurance is unavailable or denied, predictable cash pricing is available through partner pharmacies.

Coverage depends on your insurance provider’s policies and clinical criteria.

The process is simple:

1. Complete a secure online consultation with a licensed medical provider.

2. Your provider reviews your medical history to confirm whether Zepbound is appropriate.

3. If prescribed, Zepbound is shipped FREE and discreetly from a licensed U.S. pharmacy.

Our care team remains available for ongoing support, dose adjustments, refill coordination, and treatment questions.