NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell and is essential for cellular energy production, DNA repair, mitochondrial function, and metabolic health. While NAD+ is not FDA-approved to treat any disease, many individuals use NAD+ therapy as part of a comprehensive wellness program.

Common wellness uses include supporting healthy aging, enhancing cellular resilience, maintaining metabolic efficiency, and promoting overall vitality. NAD+ levels naturally decline with age, stress, poor sleep, and environmental factors, so replenishment may support healthy cellular function.

NAD+ plays a central role in mitochondrial activity — the process your cells use to generate ATP, also known as cellular energy. NAD+ also activates proteins called sirtuins, which are involved in metabolic regulation and cellular repair.

As we age, NAD+ levels decline significantly, which may impact energy, cognition, and cellular function. By supporting healthier NAD+ levels, supplementation may help promote efficient energy production and healthy cellular performance.

While individual results vary, people commonly use NAD+ therapy for wellness purposes such as:

• Supporting cellular energy and stamina
• Promoting cognitive clarity and mental focus
• Maintaining healthy metabolic function
• Supporting recovery from daily stress
• Encouraging healthy aging at the cellular level

NAD+ is not a medical treatment for chronic diseases, but it may complement general wellness and lifestyle routines.

Some individuals report subtle improvements in energy, clarity, or focus within the first few days of using injectable NAD+. Others may notice gradual changes after several weeks of consistent use.

The timeline depends on factors such as dosage, frequency, wellness goals, sleep, metabolic health, and overall lifestyle. Your provider will tailor a dosing schedule that aligns with your needs.

When prescribed and taken under medical supervision, NAD+ is generally considered safe. Most reported effects are mild, temporary, and dose-related. Providers often adjust dosing to improve tolerance and balance comfort with results.

Because NAD+ interacts with core metabolic pathways, individuals with specific medical conditions should review their health history with a licensed provider prior to starting therapy.

Potential side effects vary depending on dose and individual sensitivity. Possible effects may include:

• Mild headache
• Nausea or digestive discomfort
• Warm flushing or tingling sensations
• Temporary fatigue
• Slight injection site irritation (injectable protocols only)

These effects typically decrease as the body adapts or dosing is adjusted by the provider.

No. NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are NAD+ precursors — your body converts them into NAD+.

Injectable NAD+ delivers the molecule directly, allowing for more predictable absorption and immediate availability. Many patients who don’t respond to precursors find improved results with direct NAD+ supplementation.

NAD+ is not a weight-loss medication and is not intended to replace GLP-1 therapies. It does not directly cause fat loss. However, because NAD+ plays a vital role in energy metabolism and cellular efficiency, some individuals find it easier to maintain exercise routines, focus, and recovery — all of which can complement a healthy lifestyle.

NAD+ should not be used as a primary weight-loss therapy.

NAD+ is considered a wellness therapy rather than a medical necessity, so it is rarely covered by insurance plans. Most patients use cash-pay pricing for NAD+ therapy.

Good Girl Rx provides transparent pricing with no hidden fees.

Starting NAD+ therapy is simple:

1. Fill out a brief online health intake form.
2. Complete a telehealth consultation with a licensed provider.
3. Receive a personalized NAD+ protocol tailored to your goals.
4. Your NAD+ prescription ships directly to your home with step-by-step instructions.

Your provider will review dosing, timing, safety considerations, and what to expect as you begin therapy.